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Luminescence approaches for the rapid detection of disease-related receptor proteins using transition metal-based probes

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Abstract

Protein biomarkers, particularly abnormally expressed receptor proteins, have been proved to be one of the crucial biomarkers for the rapid assessment, diagnosis, prognosis and prediction of specific human diseases. Transition metal based strategies in particular possess delightful strengths in the in-field and real-time visualization of receptor proteins owing to their unique photophysical properties. In this review, we highlight recent advances in the development of detection methods for receptor protein biomarkers using transition metal based approaches, particularly those employing transition metal complexes. We first discuss the strengths and weaknesses of various strategies used for protein biomarker monitoring in live cells. We then describe the principles of the various sensing platforms and their application for receptor protein detection. Finally, we discuss the challenges and future inspirations in this specific field.

Graphical abstract: Luminescence approaches for the rapid detection of disease-related receptor proteins using transition metal-based probes

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Publication details

The article was received on 02 Sep 2019, accepted on 01 Oct 2019 and first published on 02 Oct 2019


Article type: Review Article
DOI: 10.1039/C9TB01889A
J. Mater. Chem. B, 2019, Advance Article

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    Luminescence approaches for the rapid detection of disease-related receptor proteins using transition metal-based probes

    D. Ma, C. Wu, H. Liu, K. Wu and C. Leung, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01889A

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