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Construction of DOX/APC co-loaded BiOI@CuS NPs for safe and highly effective CT imaging and chemo-photothermal therapy of lung cancer

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Abstract

Recently, a variety of nanoparticles have been widely used as imaging agents or carriers for the diagnosis and therapy of lung cancer. However, their poor imaging effect, high toxicity, pro-inflammatory effect and ineffective treatment are still a great challenge. In this work, we reported a novel kind of BiOI@CuS nanoparticle to achieve safe and effective therapy of lung cancer by co-loading hydrochloric acid doxorubicin (DOX) and aspirin phenacetin and caffeine (APC). The nanoparticles can effectively relieve inflammatory reactions induced by photo-thermal therapy (PTT). In vitro and in vivo assays showed that DOX/APC co-loaded BiOI@CuS exhibited an effective chemo-photothermal comprehensive therapy effect and good CT imaging capability. Consequently, this multifunctional nanosystem provides a versatile and promising platform in the imaging and treatment of lung cancer in further applications.

Graphical abstract: Construction of DOX/APC co-loaded BiOI@CuS NPs for safe and highly effective CT imaging and chemo-photothermal therapy of lung cancer

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Publication details

The article was received on 31 Aug 2019, accepted on 11 Oct 2019 and first published on 23 Oct 2019


Article type: Paper
DOI: 10.1039/C9TB01874C
J. Mater. Chem. B, 2019, Advance Article

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    Construction of DOX/APC co-loaded BiOI@CuS NPs for safe and highly effective CT imaging and chemo-photothermal therapy of lung cancer

    Y. Zhang, R. Wang, W. Li, G. Huang, J. Zhu, J. Cheng and D. He, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01874C

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