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In vivo two-photon imaging/excited photothermal therapy strategy of a silver-nanohybrid

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Abstract

A multi-functional nanohybrid (PyAnOH-Ag) with both a two-photon photothermal therapy (TP-PTT) effect and two-photon excited fluorescence (TPEF) imaging performance has been fabricated based on interfacial coordination interactions. The hybrid possesses a high two-photon absorption cross section (δTPA, 4638 GM) and detectable TPEF signals, which leads to excellent two-photon photothermal conversion. Upon irradiation at 840 nm, the temperature of the PyAnOH-Ag-PBS suspension reaches 42 °C in just 4 min, which results in 80% photothermal toxicity on HepG2 cells. The detectable TPEF signals can be used to monitor the cell ablation procedure. Moreover, PyAnOH-Ag exhibits a good phototherapeutic effect on tumor tissue of H22-modelled mice with almost 100% tumor growth inhibition under 840 nm irradiation for 10 min, which is superior to many reported photothermal agents. This strategy of TPEF guided TP-PTT agents can be potentially applied in a variety of therapeutic agents with monitoring ability.

Graphical abstract: In vivo two-photon imaging/excited photothermal therapy strategy of a silver-nanohybrid

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Publication details

The article was received on 18 Aug 2019, accepted on 21 Oct 2019 and first published on 07 Nov 2019


Article type: Paper
DOI: 10.1039/C9TB01769K
J. Mater. Chem. B, 2019, Advance Article

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    In vivo two-photon imaging/excited photothermal therapy strategy of a silver-nanohybrid

    Z. Huang, L. Gao, L. Kong, H. Zhang, J. Yang and L. Li, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01769K

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