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Progress in electrospun composite nanofibers: composition, performance and applications for tissue engineering

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Abstract

The discovery of novel methods to fabricate optimal scaffolds that mimic both mechanical and functional properties of the extracellular matrix (ECM) has always been the “holy grail” in tissue engineering. In recent years, electrospinning has emerged as an attractive material fabrication method and has been widely applied in tissue engineering due to its capability of producing non-woven and nanoscale fibers. However, from the perspective of biomimicry, it is difficult for single-component electrospun fiber membranes to achieve the biomimetic purposes of the multi-component extracellular matrix. Based on electrospinning, various functional components can be efficiently and expediently introduced into the membranes, and through the complementation and correlation of the properties of each component, composite materials with comprehensive and superior properties are obtained while maintaining the primitive merits of each component. In this review, we will provide an overview of the attempts made to fabricate electrospinning-based composite tissue engineering materials in the past few decades, which have been divided into organic additives, inorganic additives and organic–inorganic additives.

Graphical abstract: Progress in electrospun composite nanofibers: composition, performance and applications for tissue engineering

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Publication details

The article was received on 14 Aug 2019, accepted on 04 Oct 2019 and first published on 08 Oct 2019


Article type: Review Article
DOI: 10.1039/C9TB01730E
J. Mater. Chem. B, 2019, Advance Article

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    Progress in electrospun composite nanofibers: composition, performance and applications for tissue engineering

    X. Gao, S. Han, R. Zhang, G. Liu and J. Wu, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01730E

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