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Supramolecular and dynamic covalent hydrogel scaffolds: from gelation chemistry to enhanced cell retention and cartilage regeneration

Abstract

Supramolecular and dynamic covalent crosslinking (DCC) hydrogels not only display unique physicochemical properties that can mimic the dynamic extracellular matrix (ECM), but also have the capabilities of shear-thinning, self-healing and even shape memorizing. Specifically, through breaking and reforming of the reversible linkage cells can be readily encapsulated in the matrix and well maintain their differentiation potentials. The dynamic shear-thinning and self-healing hydrogels can be also explored as cell-compatible bio-inks for the design of complex multicellular structures. These distinctive properties of dynamic hydrogels have attracted increasing interests in cell retention as well as cartilage tissue engineering. The biophysical and biochemical cues of hydrogel matrices have significant effect on cell fate. The studies of the relationship of cell response and critical properties of hydrogels, such as mechanical strength, elasticity, ligand chemistry and degradation, are helpful in advancing dynamic hydrogels for cell retention and delivery. In this review, we highlight the most recent progress in gelation strategies of biomedical supramolecular and DCC hydrogels, and then focus on their applications for enhancing cell retention and cartilage/osteochondral regeneration. Further, the challenges and future perspectives of supramolecular and DCC hydrogels in cell retention and cartilage regeneration are also discussed.

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Publication details

The article was received on 10 Aug 2019, accepted on 04 Oct 2019 and first published on 07 Oct 2019


Article type: Review Article
DOI: 10.1039/C9TB01698H
J. Mater. Chem. B, 2019, Accepted Manuscript

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    Supramolecular and dynamic covalent hydrogel scaffolds: from gelation chemistry to enhanced cell retention and cartilage regeneration

    L. Teng, Y. Chen, Y. Jia and L. Ren, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C9TB01698H

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