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Issue 40, 2019
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One-pot preparation of double network hydrogels via enzyme-mediated polymerization and post-self-assembly for wound healing

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Abstract

Hybrid hydrogels combining polymers and low-molecular-weight gelators (LMWGs) are promising soft materials. Self-assembled LMWG-based supramolecular networks via noncovalent interactions exhibit excellent reversible thixotropy, which are usually incorporated into polymer gel networks generating functional double network hybrid hydrogels. In this study, we used enzyme-mediated polymerization and post-self-assembly for the one-pot preparation of LMWG-based hybrid hydrogels which consist of a covalently cross-linked polyacrylamide as the first chemical network and post-self-assembled DBS-COOH as the second supramolecular network. The gelation processes are monitored by the EPR measurement and 1H NMR characterization. The DBS-COOH gel network endows the hybrid gel with a well-controlled release behaviour of an anti-inflammatory drug—diclofenac sodium (DCF). Further in vivo wound healing experiments elucidated that the hybrid gel is a promising candidate material for biomedical applications. The enzymatic one-pot preparation principle will provide a unique viewpoint for fabricating functional LMWG/polymer hybrid hydrogels.

Graphical abstract: One-pot preparation of double network hydrogels via enzyme-mediated polymerization and post-self-assembly for wound healing

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Publication details

The article was received on 07 Aug 2019, accepted on 04 Sep 2019 and first published on 05 Sep 2019


Article type: Paper
DOI: 10.1039/C9TB01667H
J. Mater. Chem. B, 2019,7, 6195-6201

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    One-pot preparation of double network hydrogels via enzyme-mediated polymerization and post-self-assembly for wound healing

    Q. Wei, Y. Chang, G. Ma, W. Zhang, Q. Wang and Z. Hu, J. Mater. Chem. B, 2019, 7, 6195
    DOI: 10.1039/C9TB01667H

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