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pH-Responsive polyelectrolyte coated gadolinium oxide-doped mesoporous silica nanoparticles (Gd2O3@MSNs) for synergistic drug delivery and magnetic resonance imaging enhancement

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Abstract

Theranostic platforms that combine therapeutic and imaging modalities have received increasing interest. The development of theranostic nanovectors that can release therapeutic agents at pathological tissues in an on-demand manner and provide instantaneous feedback through non-invasive imaging techniques is of urgent need. Herein, a new magnetic resonance imaging (MRI) contrast agent, gadolinium oxide (Gd2O3), and an anticancer drug, doxorubicin (DOX), were co-loaded into mesoporous silica nanoparticles (MSNs) with the formation of hybrid Gd2O3@MSN-DOX nanoparticles. The hybrid nanoparticles were further coated with pH-responsive polyelectrolytes that underwent a charge reversal process at acidic pH. Upon entering into cells by folic acid (FA) receptor-mediated endocytosis, the mildly acidic pH within endolysosomes triggered the disassociation of the absorbed polyelectrolytes on the surfaces of the Gd2O3@MSN-DOX nanoparticles and thus actuated the DOX release, thereby exerting an anti-cancer effect. More importantly, the confinement of paramagnetic Gd2O3 within MSNs led to a remarkable increase of MRI relaxivity (r1 = 9.14 mM−1 s−1 vs. 3.68 mM−1 s−1 of the clinically applied MRI contrast agent), likely due to the increased tumbling time and coordination number of water molecules. This work provides a feasible strategy to fabricate theranostic nanovectors with controlled release behavior triggered by mildly acidic pH and high-performance MR imaging capability.

Graphical abstract: pH-Responsive polyelectrolyte coated gadolinium oxide-doped mesoporous silica nanoparticles (Gd2O3@MSNs) for synergistic drug delivery and magnetic resonance imaging enhancement

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Publication details

The article was received on 06 Aug 2019, accepted on 28 Sep 2019 and first published on 10 Oct 2019


Article type: Paper
DOI: 10.1039/C9TB01654F
J. Mater. Chem. B, 2019, Advance Article

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    pH-Responsive polyelectrolyte coated gadolinium oxide-doped mesoporous silica nanoparticles (Gd2O3@MSNs) for synergistic drug delivery and magnetic resonance imaging enhancement

    K. He, J. Li, Y. Shen and Y. Yu, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01654F

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