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Light-driven visualization of endogenous cysteine, homocysteine, and glutathione using a near-infrared fluorescent probe

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Abstract

Herein, we presented a hydrosoluble triple-site and triple-excitation alternative NIR fluorescent probe for visualization of endogenous biothiols in phosphate-buffered saline (pH 7.4, 10 mM). Upon irradiation using different excitation light, probe 1 exhibited different fluorescence responses upon the addition of Cys, Hcy, and GSH: λex = 419 nm, λem = 498 nm; λex = 518 nm, λem = 573, 616, 727, and 783 nm; λex = 555 nm, λem = 612 and 727 nm, respectively. Furthermore, 1 was favourably applied for bioimaging endogenous Cys, Hcy, and GSH in A375 cells through well-defined blue–green–red emission channels.

Graphical abstract: Light-driven visualization of endogenous cysteine, homocysteine, and glutathione using a near-infrared fluorescent probe

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Publication details

The article was received on 04 Aug 2019, accepted on 02 Nov 2019 and first published on 05 Nov 2019


Article type: Paper
DOI: 10.1039/C9TB01645G
J. Mater. Chem. B, 2019, Advance Article

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    Light-driven visualization of endogenous cysteine, homocysteine, and glutathione using a near-infrared fluorescent probe

    Y. Yang, Y. Wang, Y. Feng, C. Cao, X. Song, G. Zhang and W. Liu, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01645G

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