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Multifunctional drug carrier on the basis of 3d–4f Fe/La-MOFs for drug delivery and dual-mode imaging

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Abstract

Multifunctional drug carriers for simultaneous imaging and drug delivery have emerged as an important new direction for the treatment of cancer. In this study, 3d–4f heterometallic Fe/La-MOFs, with excellent fluorescence and superior positive magnetic resonance imaging with high resolution, were synthesized successfully. The feasibility of Fe/La-MOFs for use in multifunctional drug delivery was demonstrated using doxorubicin hydrochloride (DOX) as the drug model. After modification with tunable amino modified silica layers, the drug loading increased to 150.2 mg g−1 from 23.9 mg g−1, and the pH responsive drug release climbed 80% from 10% upon regulating the pH from 5.8 to 7.4. T2-Weighted magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) both showed a clear concentration-dependent contrast enhancement, indicating potential application as a MRI/FOI dual mode imaging agent. In addition, the FOI of 4T1 cells loaded with Fe/La-MOFs demonstrated their capacity for imaging living cells. The particles were tracked by MRI, and the transverse relativity (r2) ranks among the highest reported for Fe3+complexes (100.49 mM−1 s−1). In summary, this is the first report on 3d–4f MOF particles displaying pH-responsive delivery and MRI/FOI dual mode imaging.

Graphical abstract: Multifunctional drug carrier on the basis of 3d–4f Fe/La-MOFs for drug delivery and dual-mode imaging

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Publication details

The article was received on 20 Jul 2019, accepted on 14 Sep 2019 and first published on 18 Sep 2019


Article type: Paper
DOI: 10.1039/C9TB01509D
J. Mater. Chem. B, 2019, Advance Article

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    Multifunctional drug carrier on the basis of 3d–4f Fe/La-MOFs for drug delivery and dual-mode imaging

    C. Lin, B. Chi, C. Xu, C. Zhang, F. Tian, Z. Xu, L. Li, A. K. Whittaker and J. Wang, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01509D

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