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Issue 35, 2019
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Accelerated discovery and mechanical property characterization of bioresorbable amorphous alloys in the Mg–Zn–Ca and the Fe–Mg–Zn systems using high-throughput methods

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Abstract

Ternary amorphous alloys in the magnesium (Mg)–zinc (Zn)–calcium (Ca) and the iron (Fe)–Mg–Zn systems are promising candidates for use in bioresorbable implants and devices. The optimal alloy compositions for biomedical applications should be chosen from a large variety of available alloys with best combination of mechanical properties (modulus, strength, hardness) and biological response (in situ degradation rates, cell adhesion and proliferation). As a first step towards establishing a database designed to enable such targeted material selection, amorphous alloy composition libraries were fabricated employing a combinatorial magnetron sputtering approach where Mg, Zn, and Ca/Fe are co-deposited from separate sources onto a silicon wafer substrate. Composition analysis using energy dispersive X-ray spectroscopy documented a composition range of ∼15–85 at% Mg, ∼6–55 at% Zn, and ∼5–60 at% Ca for the Mg–Zn–Ca library and ∼26–84 at% Mg, ∼10–61 at% Zn, and ∼7–55 at% Fe for the Fe–Mg–Zn library. X-ray diffraction measurements established that amorphous alloys (i.e., glasses) form in almost the entire range of composition at the high cooling rates during sputtering for both alloy libraries. Finally, the effective material modulus, the Oliver–Pharr hardness, and the yield strength values obtained using nanoindentation reveal a wide range of mechanical properties within both systems.

Graphical abstract: Accelerated discovery and mechanical property characterization of bioresorbable amorphous alloys in the Mg–Zn–Ca and the Fe–Mg–Zn systems using high-throughput methods

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Publication details

The article was received on 28 Jun 2019, accepted on 02 Aug 2019 and first published on 14 Aug 2019


Article type: Paper
DOI: 10.1039/C9TB01302D
J. Mater. Chem. B, 2019,7, 5392-5400

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    Accelerated discovery and mechanical property characterization of bioresorbable amorphous alloys in the Mg–Zn–Ca and the Fe–Mg–Zn systems using high-throughput methods

    A. Datye, S. Alexander Kube, D. Verma, J. Schroers and U. D. Schwarz, J. Mater. Chem. B, 2019, 7, 5392
    DOI: 10.1039/C9TB01302D

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