Jump to main content
Jump to site search


Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent

Author affiliations

Abstract

Structure-based targeting of fluorescent dyes is essential for their use as imaging agents for disease diagnosis. Here, we describe the development of the benzoquinolizinium compound Medical fluorophore 1 (MF1) as a novel biomedical imaging agent that allows the visualization of inflammation by virtue of its unique chemical structure. Lipopolysaccharide treatment stimulated the uptake of MF1 by bone marrow-derived macrophages, with no adverse effects on cell proliferation. In vivo fluorescence lifetime imaging revealed the accumulation of MF1 in carrageenan-induced acute inflammatory lesions in mice, which peaked at 6 h. MF1-based imaging also allowed monitoring of the response to the anti-inflammatory drugs dexamethasone and sulfasalazine. Thus, MF1 can be used to diagnose diseases characterized by inflammation as well as treatment efficacy.

Graphical abstract: Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Jun 2019, accepted on 14 Oct 2019 and first published on 18 Oct 2019


Article type: Paper
DOI: 10.1039/C9TB01266D
J. Mater. Chem. B, 2019, Advance Article

  •   Request permissions

    Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent

    S. B. Lee, Y. R. Han, H. Jeon, C. Jun, S. Kim, J. Chin, S. Lee, M. Jeong, J. Lee, C. Lee, S. J. Cho, D. Kim and Y. H. Jeon, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01266D

Search articles by author

Spotlight

Advertisements