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A photodynamic antibacterial spray-coating based on the host–guest immobilization of the photosensitizer methylene blue

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Abstract

In the “post-antibiotic era”, healthcare-associated infection has become a global problem that threatens public health and causes huge economic losses. The development of antibacterial coatings based on non-antibiotic strategies is particularly important as drug-resistant bacteria continue to evolve. Photodynamic coatings are a high potential method to treat bacteria, however, the aggregation of photosensitizers on the coating affects the photodynamic capacity seriously. Herein, a photodynamic coating is developed based on the host–guest interaction between β-cyclodextrin and the photosensitizer methylene blue (MB). The host–guest interaction avoids aggregation of MB and results in a high singlet oxygen quantum yield. Consequently, efficient photoantibacterial activity towards methicillin-resistant Staphylococcus aureus is achieved by the photodynamic coating with very low MB density (0.53 ± 0.06 μg cm−2).

Graphical abstract: A photodynamic antibacterial spray-coating based on the host–guest immobilization of the photosensitizer methylene blue

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Publication details

The article was received on 29 May 2019, accepted on 15 Jul 2019 and first published on 15 Jul 2019


Article type: Paper
DOI: 10.1039/C9TB01069F
J. Mater. Chem. B, 2019, Advance Article

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    A photodynamic antibacterial spray-coating based on the host–guest immobilization of the photosensitizer methylene blue

    T. Yao, J. Wang, Y. Xue, W. Yu, Q. Gao, L. Ferreira, K. Ren and J. Ji, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01069F

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