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NIR fluorescence probes with good water-solubility for detection of amyloid beta aggregates in Alzheimer’s disease

Abstract

Two quinoline-malononitrile-based NIR fluorescent probes with good water-solubility have been developed for detecting and imaging of Aβ aggregates in Alzheimer’s disease. In vitro studies demonstrated that both probes exhibited high affinity to Aβ aggregates with the increase of fluorescence intensity due to the intramolecular charge transfer effect. Moreover, the probes could particularly image Aβ plaques in brain sections from triple transgenic mice of AD.

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Publication details

The article was received on 20 May 2019, accepted on 08 Aug 2019 and first published on 09 Aug 2019


Article type: Paper
DOI: 10.1039/C9TB01012B
J. Mater. Chem. B, 2019, Accepted Manuscript

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    NIR fluorescence probes with good water-solubility for detection of amyloid beta aggregates in Alzheimer’s disease

    M. Xu, R. Li, X. Li, G. Lv, S. Li, A. Sun, Y. Zhou and T. Yi, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C9TB01012B

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