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Nanoarchitectured peroxidase-mimetic nanozymes: mesoporous nanocrystalline α- or γ-iron oxide?

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Abstract

Nanozymes (nanoparticles with enzyme-like properties) have attracted considerable attention in recent years owing to their intrinsic enzyme-like properties and broad application in the fields of ELISA based immunoassay and biosensing. Herein, we systematically investigate the influence of crystal phases (γ-Fe2O3 and α-Fe2O3) of mesoporous iron oxide (IO) on their peroxidase mimetic activity. In addition, we have also demonstrated the applicability of these mesoporous IOs as nanozymes for detecting the glucose biomarker with a limit of detection (LOD) of 0.9 μM. Mesoporous γ-Fe2O3 shows high nanozyme activities (and magnetism) toward the catalytic oxidation of chromogenic substances, such as 3,3′,5,5′-tetramethylbenzidine (TMB) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-ABTS, as well as for the colourimetric detection of glucose, compared to that of α-Fe2O3. We believe that this in-depth study of crystal structure based nanozyme activity will guide designing highly effective nanozymes based on iron oxide nanostructures for chemical sensing, biosensing and environmental remediation.

Graphical abstract: Nanoarchitectured peroxidase-mimetic nanozymes: mesoporous nanocrystalline α- or γ-iron oxide?

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Publication details

The article was received on 16 May 2019, accepted on 24 Jul 2019 and first published on 15 Aug 2019


Article type: Paper
DOI: 10.1039/C9TB00989B
J. Mater. Chem. B, 2019, Advance Article

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    Nanoarchitectured peroxidase-mimetic nanozymes: mesoporous nanocrystalline α- or γ-iron oxide?

    M. K. Masud, J. Kim, Md. M. Billah, K. Wood, M. J. A. Shiddiky, N. Nguyen, R. K. Parsapur, Y. V. Kaneti, A. A. Alshehri, Y. G. Alghamidi, K. A. Alzahrani, M. Adharvanachari, P. Selvam, Md. S. A. Hossain and Y. Yamauchi, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB00989B

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