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Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s for biomedical applications

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Abstract

An approach for the preparation of self-healing and injectable hydrogels based on the crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s is reported. Hydrogelation does not require any organic solvents, as the polymers dissolve in water below their lower critical solution temperatures. The transplanted hydrogels cause no significant foreign-body response. Considering the simplicity of the method and the biocompatibility of the resulting injectable hydrogels, crystallization-driven hydrogelation of poly(oxazoline)-based polymers may potentially be used in a wide range of biomedical applications.

Graphical abstract: Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s for biomedical applications

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Publication details

The article was received on 08 May 2019, accepted on 02 Jul 2019 and first published on 09 Jul 2019


Article type: Paper
DOI: 10.1039/C9TB00918C
J. Mater. Chem. B, 2019, Advance Article

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    Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s for biomedical applications

    T. Nishimura, N. Sumi, S. Mukai, Y. Sasaki and K. Akiyoshi, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB00918C

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