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Issue 30, 2019
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Self-destructive PEG–BODIPY nanomaterials for photodynamic and photothermal therapy

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Abstract

Photoactive nanoparticles are an important platform for multimodal imaging and phototherapy of tumors. Herein, amphiphilic photosensitizers were made from boron dipyrromethene (BODIPY) and poly(ethylene glycol) (PEG2k) by using a thioketal linker, which is reactive oxygen species-responsive. The photosensitizers could form stable nanoparticles in aqueous solution. The resulting nanoparticles could simultaneously produce heat and reactive oxygen species upon irradiation to achieve combined photothermal and photodynamic therapy. The produced singlet oxygen could destroy the thioketal linker, and accelerate the destruction of nanoparticles. In addition, the near-infrared fluorescence and photoacoustic imaging ability of nanoparticles can reflect the biodistribution and destiny of nanoparticles. This work highlights the application of integrated diagnostic and therapeutic photosensitizers in carriers.

Graphical abstract: Self-destructive PEG–BODIPY nanomaterials for photodynamic and photothermal therapy

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Supplementary files

Article information


Submitted
18 Apr 2019
Accepted
27 Jun 2019
First published
28 Jun 2019

J. Mater. Chem. B, 2019,7, 4655-4660
Article type
Paper

Self-destructive PEG–BODIPY nanomaterials for photodynamic and photothermal therapy

C. Li, W. Lin, S. Liu, W. Zhang and Z. Xie, J. Mater. Chem. B, 2019, 7, 4655
DOI: 10.1039/C9TB00752K

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