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Issue 22, 2019
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Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood

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Abstract

We report a large scale preparation of bioimprints of layers of cultured human leukemic HL60 cells which can perform cell shape and size recognition from a mixture with peripheral blood mononuclear cells (PBMCs). We demonstrate that the bioimprint-cell attraction combined with surface modification and flow rate control allows depletion of the HL60 cells from peripheral blood which can be used for development of alternative therapies of acute myeloid leukaemia (AML).

Graphical abstract: Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood

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Publication details

The article was received on 08 Apr 2019, accepted on 25 Apr 2019 and first published on 07 May 2019


Article type: Communication
DOI: 10.1039/C9TB00679F
J. Mater. Chem. B, 2019,7, 3497-3504

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    Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood

    A. A.K. Das, J. Medlock, H. Liang, D. Nees, D. J. Allsup, L. A. Madden and V. N. Paunov, J. Mater. Chem. B, 2019, 7, 3497
    DOI: 10.1039/C9TB00679F

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