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Oily core/amphiphilic polymer shell nanocapsules change the intracellular fate of doxorubicin in breast cancer cells

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Abstract

The aim of this work was to develop and test the in vitro biological activity of nanocapsules loaded with a doxorubicin (DOX) free base dissolved in a core of castor oil shelled by poly(methyl vinyl ether-co-maleic anhydride) conjugated to n-octadecylamine residues. This system was stable and monodisperse, with a hydrodynamic diameter of about 300 nm. These nanocapsules changed the intracellular distribution of DOX, from the nuclei to the cytoplasm, and exhibited higher toxicity towards cancer cells – 4T1 and MCF-7 – and significantly lower toxicity towards normal cells – NIH-3T3 and MCF-10A – in vitro. In conclusion, these nanocapsules are suitable DOX carriers, which remain to be studied in in vivo tumor models.

Graphical abstract: Oily core/amphiphilic polymer shell nanocapsules change the intracellular fate of doxorubicin in breast cancer cells

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Publication details

The article was received on 25 Mar 2019, accepted on 02 May 2019 and first published on 02 May 2019


Article type: Paper
DOI: 10.1039/C9TB00587K
J. Mater. Chem. B, 2019, Advance Article

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    Oily core/amphiphilic polymer shell nanocapsules change the intracellular fate of doxorubicin in breast cancer cells

    J. M. Coelho, N. S. Camargo, R. Ganassin, M. C. O. Rocha, C. Merker, J. Böttner, I. Estrela-Lopis, K. R. Py-Daniel, K. V. Jardim, M. H. Sousa, A. S. Ombredane, G. A. Joanitti, R. C. Silva, R. B. Azevedo, J. P. F. Longo and L. A. Muehlmann, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB00587K

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