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A near-infrared responsive germanium complex of Ge/GeO2 for targeted tumor phototherapy

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Abstract

The development of photoactive nanomaterials with high biocompatibility for targeted tumor phototherapy is of great significance for antitumor applications; this study presents a novel phototherapeutic agent, the Ge/GeO2 complex, which shows broad photoabsorption in the near infrared (NIR) region. As a result, it can synchronously produce reactive oxygen species (ROS) and heat under NIR irradiation. After being loaded onto macrophages, Ge/GeO2 could be delivered to tumors in a targeted fashion. Combining the abovementioned merits together, macrophage-loaded Ge/GeO2 realized in vivo synergetic photothermal and photodynamic outcomes to completely remove solid tumors in mice via intravenous administration. In this study, B-ultrasonography was also employed to monitor the tumor evolution after phototherapy, revealing a sequential process of tumor necrosis, liquefaction/softening, and finally disappearance. In addition, Ge/GeO2 proposed in this study shows negligible cytotoxicity and hematotoxicity, especially after being loaded onto macrophages.

Graphical abstract: A near-infrared responsive germanium complex of Ge/GeO2 for targeted tumor phototherapy

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Publication details

The article was received on 21 Mar 2019, accepted on 10 Jun 2019 and first published on 11 Jun 2019


Article type: Paper
DOI: 10.1039/C9TB00548J
J. Mater. Chem. B, 2019, Advance Article

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    A near-infrared responsive germanium complex of Ge/GeO2 for targeted tumor phototherapy

    Y. Gao, S. Wang, C. Yang, N. An, Z. Liu, M. Yan and C. Guo, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB00548J

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