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Dual-channel fluorescent probe bearing two-photon activity for cell viability monitoring

Abstract

The search for highly sensitive and efficient method to monitor cell viability is a high-priority target yet challenge. In this work, two chromophores, 1OC and 2OC, have been rational designed and fabricated to achieve excellent biocompatibility and two-photon activity in near-infrared region. Fortunately, thanks to the introduction of water-soluble moiety and biocompatible triazole groups linking with ether oxygen chain via “Click” reaction, the obtained 2OC displayed considerable biocompatibility and two-photon activity. Additionally, it revealed dual-channel fluorescence microscopy imaging for nucleolar and mitochondrial targeting, which can be employed for cell viability monitoring.

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Supplementary files

Publication details

The article was received on 14 Mar 2019, accepted on 13 May 2019 and first published on 14 May 2019


Article type: Communication
DOI: 10.1039/C9TB00512A
J. Mater. Chem. B, 2019, Accepted Manuscript

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    Dual-channel fluorescent probe bearing two-photon activity for cell viability monitoring

    Y. Zhao, C. Zhang, J. Liu, D. Li, X. Tian, A. Wang, S. Li, J. Wu and Y. Tian, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C9TB00512A

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