Jump to main content
Jump to site search

Issue 24, 2019
Previous Article Next Article

Stable and self-healable LbL coating with antibiofilm efficacy based on alkylated polyethyleneimine micelles

Author affiliations

Abstract

Effective solutions are necessary for biomaterial-associated infections caused by bacteria adhesion and subsequent biofilm formation on the surface of biomedical implants/devices. Current antibacterial coatings are usually vulnerable, and their bactericidal efficacy is impaired or even eliminated upon scratching or abrasion. Thus, self-healable coatings capable of repairing defects themselves are highly desirable. In this work, N-decyl polyethyleneimine (DPEI), a cationic amphiphilic polymer able to self-assemble into micelles in water to concentrate the density of cationic charge, exhibited enhanced antibacterial activity towards the Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative Pseudomonas aeruginosa (P. aeruginosa). A layer-by-layer (LbL) assembled coating was prepared using DPEI micelles and polyacrylic acid (PAA), which could reduce more than 90% bacterial adhesion and prevent biofilm formation. In addition, the DPEI/PAA LbL-assembled coating remained stable even with rinsing in physiological saline for up to three weeks owing to the strong interaction induced by its high charge. More importantly, this antibacterial DPEI/PAA LbL-assembled coating achieved self-healing quickly under wet conditions after being scratched, preventing bacteria from adhering to the damaged areas and forming a biofilm. Importantly, this coating avoids the use of antibiotics, which is less likely to cause drug-resistance. In addition, this coating is also biocompatible with mammalian cells (C2C12 mouse myoblast). All these excellent properties endow this self-healing DPEI/PAA LbL-assembled coating with promising prospects for biomedical application.

Graphical abstract: Stable and self-healable LbL coating with antibiofilm efficacy based on alkylated polyethyleneimine micelles

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Mar 2019, accepted on 14 May 2019 and first published on 15 May 2019


Article type: Paper
DOI: 10.1039/C9TB00498J
J. Mater. Chem. B, 2019,7, 3865-3875

  •   Request permissions

    Stable and self-healable LbL coating with antibiofilm efficacy based on alkylated polyethyleneimine micelles

    Q. Wang, L. Wang, L. Gao, L. Yu, W. Feng, N. Liu, M. Xu, X. Li, P. Li and W. Huang, J. Mater. Chem. B, 2019, 7, 3865
    DOI: 10.1039/C9TB00498J

Search articles by author

Spotlight

Advertisements