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A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy

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Abstract

Targeted therapy that facilitates the on-site, on-demand action of drug combinations is a promising approach for combination chemotherapy. In situ gelling hydrogels were prepared using biopolymers with in-built imine and borate diol ester linkages to render pH and glucose responsiveness, respectively to achieve a triggered release of doxorubicin in tumor milieu. Doxorubicin prodrug hydrogel doped with miltefosine demonstrated a synergistic effect on inhibition of drug resistant MDA-MB 231 human breast cancer cells, suitable for focal combination chemotherapy.

Graphical abstract: A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy

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Publication details

The article was received on 06 Mar 2019, accepted on 06 Apr 2019 and first published on 08 Apr 2019


Article type: Communication
DOI: 10.1039/C9TB00454H
Citation: J. Mater. Chem. B, 2019, Advance Article

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    A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy

    B. Balakrishnan, N. Joshi, K. Thorat, S. Kaur, R. Chandan and R. Banerjee, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB00454H

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