Issue 18, 2019

A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy

Abstract

Targeted therapy that facilitates the on-site, on-demand action of drug combinations is a promising approach for combination chemotherapy. In situ gelling hydrogels were prepared using biopolymers with in-built imine and borate diol ester linkages to render pH and glucose responsiveness, respectively to achieve a triggered release of doxorubicin in tumor milieu. Doxorubicin prodrug hydrogel doped with miltefosine demonstrated a synergistic effect on inhibition of drug resistant MDA-MB 231 human breast cancer cells, suitable for focal combination chemotherapy.

Graphical abstract: A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2019
Accepted
06 Apr 2019
First published
08 Apr 2019

J. Mater. Chem. B, 2019,7, 2920-2925

A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy

B. Balakrishnan, N. Joshi, K. Thorat, S. Kaur, R. Chandan and R. Banerjee, J. Mater. Chem. B, 2019, 7, 2920 DOI: 10.1039/C9TB00454H

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