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Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy

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Abstract

Hydrogen therapy is an emerging and promising strategy for treatment of inflammation-related diseases owing to the excellent bio-safety of hydrogen molecules (H2), but is facing a challenge that the H2 concentration at the local disease site is hardly accumulated because of its high diffusibility and low solubility, limiting the efficacy of hydrogen therapy. Herein, we propose a nanomedicine strategy of imaging-guided tumour-targeted delivery and tumour microenvironment-triggered release of H2 to address this issue, and develop a kind of biocompatible carboxymethyl cellulose (CMC)-coated/stabilized Fe (Fe@CMC) nanoparticle with photoacoustic imaging (PAI), tumour targeting and acid responsive hydrogen release properties for cancer therapy. The Fe@CMC nanoparticles have demonstrated high intratumoural accumulation capability, high acid responsiveness, excellent PAI performance, selective cancer-killing effect and high bio-safety in vitro and in vivo. Effective inhibition of tumour growth is achieved by intravenous injection of the Fe@CMC nanoparticles, and the selective anti-cancer mechanism of Fe@CMC is discovered to be originated from the energy metabolism homeostasis regulatory function of the released H2. The proposed nanomedicine-mediated hydrogen therapy strategy will open a new window for precise, high-efficacy and safe cancer treatment.

Graphical abstract: Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy

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Publication details

The article was received on 19 Feb 2019, accepted on 21 Mar 2019 and first published on 22 Mar 2019


Article type: Communication
DOI: 10.1039/C9TB00338J
Citation: J. Mater. Chem. B, 2019, Advance Article

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    Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy

    Z. Kou, P. Zhao, Z. Wang, Z. Jin, L. Chen, B. Su and Q. He, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB00338J

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