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Heterogeneous growth of palladium nanocrystals on upconversion nanoparticles for multimodal imaging and photothermal therapy

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Abstract

Nanocomposites have been playing an increasingly significant role in the bioimaging-guided visualization of cancer physiotherapy. However, it has been a challenge to explore new diagnosis and treatment reagents with small size, good stability, and high photothermal conversion efficiency. Herein, we report a novel preparation of nanocomposites based on the heterogeneous growth of nano-palladium on the surface of upconversion nanoparticles (UCNPs). The final poly vinylpyrrolidone (PVP) modified UCNPs@Pd nanocomposites possess a small size and exhibit good monodispersity, biocompatibility and high photothermal conversion efficiency. In addition, relevant cellular assays show that based on the growth of palladium, the UCNPs@Pd-PVP nanocomposites can effectively kill HeLa cells under 808 nm laser irradiation. The nanocomposites also present effective upconversion luminescence imaging and T1 signal enhancement capability based on Er3+ and Gd3+ ions, respectively. Therefore, the nanocomposites successfully integrate upconversion luminescence imaging, magnetic resonance imaging, and photothermal therapy. This work provides new insights for the future development of multi-application materials based on the multicomponent heterogeneous growth of nanocomposites.

Graphical abstract: Heterogeneous growth of palladium nanocrystals on upconversion nanoparticles for multimodal imaging and photothermal therapy

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Publication details

The article was received on 15 Feb 2019, accepted on 01 Apr 2019 and first published on 03 Apr 2019


Article type: Paper
DOI: 10.1039/C9TB00317G
Citation: J. Mater. Chem. B, 2019, Advance Article

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    Heterogeneous growth of palladium nanocrystals on upconversion nanoparticles for multimodal imaging and photothermal therapy

    H. Zhao, L. Zhao, Z. Wang, W. Xi, S. T. Dibaba, S. Wang, L. Shi and L. Sun, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB00317G

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