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Issue 25, 2019
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Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke

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Abstract

Ischaemic stroke remains one of the leading causes of death and disability worldwide, without any long-term effective treatments targeted at regeneration. Limitations of existing and proposed cell- and drug-based therapies have led to the investigation of hydrogel-based strategies for new and improved therapies. They aim to enhance the intrinsic repair mechanisms, improve engraftment of therapeutic stem cells, and deliver drugs/biologics in a controlled manner in the post-stroke brain. The following article will explore the pathophysiology of stroke, and the need for injectable hydrogels in neural tissue engineering, focusing on a class of injectable hydrogels based on self-assembling peptides (SAPs). The various types of these materials will be addressed based on their mechanisms of self-assembly, including their novelties and benefits over conventional hydrogels, as well as recent experimental research that demonstrates the potential of these biomaterials in the treatment of stroke.

Graphical abstract: Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke

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Article information


Submitted
05 Feb 2019
Accepted
28 May 2019
First published
30 May 2019

J. Mater. Chem. B, 2019,7, 3927-3943
Article type
Review Article

Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke

A. Hong, M. Aguilar, M. P. Del Borgo, C. G. Sobey, B. R. S. Broughton and J. S. Forsythe, J. Mater. Chem. B, 2019, 7, 3927
DOI: 10.1039/C9TB00257J

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