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A modular theranostic platform for tumor therapy and its metabolic studies

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Abstract

Theranostic systems are able to detect and treat diseases with only one procedure, thus greatly lessening the pain of patients. Since each patient's disease can be considered as a new clinical subtype, it is essential to develop theranostic nanomaterials with changeable functions for personal treatment. In this work, a novel modular theranostic platform was designed to control the stimuli-responsive drug release. As a patch board, mesoporous silica nanoparticles (MSNs) were functionalized with a linear pH-responsive benzimidazole (Bz)-polyethylene glycol (PEG) chain containing a redox-responsive ferrocene (Fc) oxide stopper at the end. As the plug, the β-CD ring was initially located at the Bz position. In an acidic tumor microenvironment, the pH sensitive Bz was protonated and the complex formation constant between Bz and β-CD decreased. At the same time, the complex formation constant between Fc and β-CD increased remarkably. As a result, the β-CD ring would depart from the nanoparticle surface to the Fc position at pH 6.2 & 10 mM GSH, physically causing an “And” logic gate type drug release. Herein, a “plug and play” method was used to achieve changeable functions with only one platform. By plugging modified β-CD into the patch board, theranostic systems with changeable functions can be achieved easily.

Graphical abstract: A modular theranostic platform for tumor therapy and its metabolic studies

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Publication details

The article was received on 01 Feb 2019, accepted on 14 Mar 2019 and first published on 14 Mar 2019


Article type: Paper
DOI: 10.1039/C9TB00231F
Citation: J. Mater. Chem. B, 2019, Advance Article

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    A modular theranostic platform for tumor therapy and its metabolic studies

    K. Li, J. Li, D. Zheng, X. Zeng, C. Liu and X. Zhang, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB00231F

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