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Albumin enhances PTX delivery ability of dextran NPs and therapeutic efficacy of PTX for colorectal cancer

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Abstract

To enhance the drug delivery capability of polysaccharides, a novel strategy was designed utilizing protein as a new party to assist the encapsulation and release of PTX. Herein, the BSA–PTX complex was first prepared, and aldehyde-dextran was then successfully cross-linked with BSA–PTX to obtain pH-sensitive Dex6k–BSA–PTX nanoparticles via the Schiff base reaction. With a size of 150 nm and high drug loading, the Dex6k–BSA–PTX NPs significantly prolonged the blood half-life of PTX and could be passively targeted to tumor tissues, with a significant inhibition of the growth of tumor cells in vivo and in vitro.

Graphical abstract: Albumin enhances PTX delivery ability of dextran NPs and therapeutic efficacy of PTX for colorectal cancer

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Publication details

The article was received on 26 Jan 2019, accepted on 19 Apr 2019 and first published on 22 Apr 2019


Article type: Paper
DOI: 10.1039/C9TB00181F
J. Mater. Chem. B, 2019, Advance Article

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    Albumin enhances PTX delivery ability of dextran NPs and therapeutic efficacy of PTX for colorectal cancer

    X. Zhang, R. Zhang, J. Huang, M. Luo, X. Chen, Y. Kang and J. Wu, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB00181F

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