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Anthracene functionalized BODIPY derivative with singlet oxygen storage ability for photothermal and continuous photodynamic synergistic therapy

Abstract

Singlet oxygen (1O2) generated from the photosensitized process within tumor tissues during photodynamic therapy (PDT) is self-limiting. Fractional delivery of light tends to be a better method for PDT. Herein, BDPIA with a high 1O2 quantum yield (QY) of 70% has an additional anthracene module for capturing 1O2, which would be useful in PDT. In the light cycle, the endoperoxide of anthracene is generated with singlet oxygen while in the dark cycle, the endoperoxide undergoes thermal cycloreversion to produce 1O2, regenerating the anthracene module. Therefore, the photodynamic process can continue in the dark period as well as the light cycles, promising their continuous phototherapy efficacy. In addition, BDPIA NPs in water exhibit a high photothermal conversion efficiency (η = 38.9%) for effective photothermal therapy. In vitro MTT assay shows that BDPIA NPs have a low half inhibitory concentration (IC50) of 6.293 μg/mL on HeLa cells. Furthermore, lentiviral vectors transfected HeLa cell lines with red fluorescent proteins was used to perform the real time in vivo fluorescence imaging guided phototherapy. The model can monitor the real-time uptake of BDPIA NPs. The results indicate that BDPIA NPs are capable of inhibiting cell proliferation even at a low dosage (0.2 mg/kg) while the normal tissues (heart, liver, spleen, lung and kidney) suffer from no side effects. Our results demonstrate that BDPIA NPs with high phototoxicity, low dark toxicity and excellent bio-compatibility can be used a potential photosensitizer for continuous photodynamic and photothermal synergistic therapy.

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Publication details

The article was received on 26 Jan 2019, accepted on 09 Apr 2019 and first published on 10 Apr 2019


Article type: Paper
DOI: 10.1039/C9TB00180H
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript

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    Anthracene functionalized BODIPY derivative with singlet oxygen storage ability for photothermal and continuous photodynamic synergistic therapy

    J. Zhu, J. Zou, J. Zhang, Y. Sun, X. Dong and Q. Zhang, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C9TB00180H

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