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Development of a two-photon fluorescent probe for the selective detection of β-galactosidase in living cells and tissues

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Abstract

The development of two-photon bio-imaging probes for trapping specific enzyme activities in overexpressed tissue is very practical and significant. In this work, we developed a two-photon fluorescent β-gal probe G-GAL, which was made with GCTPOC as the fluorescence reporter and a β-galactosidase cleavable crew as the enzyme activity initiator. The purpose of designing this probe was to detect β-galactosidase in living cells and tissues. The probe G-GAL has the advantage of rapid response, great fluorescence enhancement and superior specificity. Furthermore, the probe has excellent tissue penetration.

Graphical abstract: Development of a two-photon fluorescent probe for the selective detection of β-galactosidase in living cells and tissues

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Publication details

The article was received on 25 Jan 2019, accepted on 15 Apr 2019 and first published on 16 Apr 2019


Article type: Paper
DOI: 10.1039/C9TB00175A
J. Mater. Chem. B, 2019, Advance Article

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    Development of a two-photon fluorescent probe for the selective detection of β-galactosidase in living cells and tissues

    Z. Li, M. Ren, L. Wang, L. Dai and W. Lin, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB00175A

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