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Bacterial acidity-triggered antimicrobial activity of self-assembling peptide nanofibers

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Abstract

A self-assembling peptide nanofiber was developed to sense the microenvironmental pH change associated with bacterial growth. Using a near-infrared probe, a strong correlation was observed between the local pH reduction of bacterial colonies with the degree of peptide disassembly, which led to their enhanced antimicrobial activity against anaerobic bacteria.

Graphical abstract: Bacterial acidity-triggered antimicrobial activity of self-assembling peptide nanofibers

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Publication details

The article was received on 20 Jan 2019, accepted on 05 Apr 2019 and first published on 05 Apr 2019


Article type: Communication
DOI: 10.1039/C9TB00134D
Citation: J. Mater. Chem. B, 2019, Advance Article

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    Bacterial acidity-triggered antimicrobial activity of self-assembling peptide nanofibers

    W. Chen, S. Li, P. Renick, S. Yang, N. Pandy, C. Boutte, K. T. Nguyen, L. Tang and H. Dong, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB00134D

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