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Novel phthalocyanine-based polymeric micelle with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy

Abstract

Photothermal therapy (PTT) has emerged one of the promising methodologies for the treatment of the cancer disease, and the ideal photothermal agents require biodegradable property and strong optical absorbance in the near-infrared (NIR) optical window. Here we report a new phthalocyanine molecule 4OCSPC, which makes the absorbance edge expand to 850 nm. Under 808-nm NIR laser irradiation, 4OCSPC polymeric micelles showed robust photostability and high photothermal conversion of 47.0%. Among them, 4OCSPC polymeric micelles exhibit a high in vivo PTT efficacy against mice bearing 4T1 tumors.

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Publication details

The article was received on 03 Jan 2019, accepted on 07 Feb 2019 and first published on 09 Feb 2019


Article type: Communication
DOI: 10.1039/C9TB00011A
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript

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    Novel phthalocyanine-based polymeric micelle with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy

    L. Li, Q. Yang, L. Shi, N. Zheng, Z. Li, K. Li, S. Qiao, T. Jia, T. Sun and Y. Wang, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C9TB00011A

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