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Issue 16, 2019
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Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study

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Abstract

A drug delivery system (DDS) for combined therapy, based on a short oxidized multiwalled carbon nanotube, is reported. It was prepared by exploiting a synthetic approach which allowed loading of two drugs, doxorubicin and metformin, the targeting agent biotin and a radiolabeling tag, to enable labeling with Ga-68 or Cu-64 in order to perform an extensive biodistribution study by PET/CT. The DDS biodistribution profile changes with different administration methods. Once administered at therapeutic doses, the DDS showed a marginal beneficial effect on 4T1 tumor bearing mice, a syngeneic and orthotopic model of triple negative breast cancer, with survival extended by 1 week and 2 days in 20% of the mice. This is encouraging given the aggressiveness of the 4T1 tumor. Furthermore, our DDS was well tolerated, ruling out concerns regarding the toxicity of carbon nanotubes.

Graphical abstract: Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study

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Publication details

The article was received on 18 Dec 2018, accepted on 06 Mar 2019 and first published on 12 Mar 2019


Article type: Paper
DOI: 10.1039/C8TB03299H
Citation: J. Mater. Chem. B, 2019,7, 2678-2687

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    Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study

    G. Biagiotti, F. Pisaneschi, S. T. Gammon, F. Machetti, M. C. Ligi, G. Giambastiani, G. Tuci, E. Powell, H. Piwnica-Worms, E. Pranzini, P. Paoli, S. Cicchi and D. Piwnica-Worms, J. Mater. Chem. B, 2019, 7, 2678
    DOI: 10.1039/C8TB03299H

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