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Dual-site functionalized NIR fluorescent material for discriminative response of concentration-dependent SO2 in cells and mice

Abstract

Sulfur dioxide (SO2), as an important anti-oxidant and gaseous signaling molecule, plays fundamental roles in regulation of intracellular signaling and cell death cellular bioenergetics. The clear visualization of SO2 level in organism is a critical step for establishing its biological functions. Therefore, it is highly demand to develop efficient analytical methods for monitor the wide concentration change of SO2 in living systems. Herein, for the first time we have successfully constructed a dual-site functionalized NIR fluorescent material (NIR-SP), which was capable of monitoring low concentration of SO2 with red fluorescence response, and blue fluorescence enhancement with high concentration SO2. Further studies absolutely confirmed the discriminative response was due to the fact that the reactivity of unsaturated C=C double bond (site I) in NIR-SP was superior to aldehyde group (site II). Additionally, the concentration-dependent manner was demonstrated by fluorescent imaging in cells and mice. We envision that this strategy would lead to insights into SO2 concentration-dependent biological effect and cell signals.

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Publication details

The article was received on 11 Dec 2018, accepted on 09 Feb 2019 and first published on 11 Feb 2019


Article type: Paper
DOI: 10.1039/C8TB03253J
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript

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    Dual-site functionalized NIR fluorescent material for discriminative response of concentration-dependent SO2 in cells and mice

    W. Zhang, F. Huo, Y. Zhang and C. Yin, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C8TB03253J

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