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Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors

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Abstract

A novel supramolecular multivalent glycosidase inhibitor was constructed based on the amphiphilic deoxynojirimycin derivative FA-DNJ. FA-DNJ self-assembled into spherical assemblies with the diameters between 103 nm and 137 nm under different pH values (pH 2–7) and showed a potent glycosidase effect against α-mannosidase with a Ki value of 0.11 μM, an effect that increased approximately 330-fold compared with that of miglitol. In addition, FA-DNJ exhibited a hypoglycaemic effect in mice.

Graphical abstract: Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors

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Publication details

The article was received on 11 Dec 2018, accepted on 23 Jan 2019 and first published on 24 Jan 2019


Article type: Communication
DOI: 10.1039/C8TB03249A
Citation: J. Mater. Chem. B, 2019, Advance Article

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    Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors

    M. Li, K. Wang, J. Yang, Y. Peng, Y. Liu, H. Zhang and X. Li, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C8TB03249A

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