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A water-soluble two-dimensional supramolecular organic framework with aggregation-induced emission for DNA affinity and live-cell imaging

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Abstract

A water-soluble two-dimensional supramolecular organic framework (2D SOF) was prepared via self-assembly of cucurbit[8]uril (CB[8]) and a three-arm flat linker molecule, which contains a benzene ring as the core and three Brooker's merocyanine (BM) analogs as arms. The strong host–guest interactions between BM and CB[8] and the directional head-to-tail stacking modes between the BM arms synergistically led to the formation of a 2D SOF. The structure of the 2D SOF was verified by 1H NMR, 2D 1H NMR NOESY, and DLS characterizations, while the monolayer structure was characterized by Cryo-TEM and AFM measurements. The 2D SOF exhibited an obvious AIE enhancement effect in H2O. In addition, DNA induced photoluminescence enhancement was observed for the monomer. As a result, this AIEgen-based 2D SOF could feature not only as a cell visualizer but also as a tracker for the nucleus in biological imaging due to the dynamic assembly process.

Graphical abstract: A water-soluble two-dimensional supramolecular organic framework with aggregation-induced emission for DNA affinity and live-cell imaging

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Publication details

The article was received on 06 Dec 2018, accepted on 15 Jan 2019 and first published on 15 Jan 2019


Article type: Paper
DOI: 10.1039/C8TB03206H
Citation: J. Mater. Chem. B, 2019, Advance Article

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    A water-soluble two-dimensional supramolecular organic framework with aggregation-induced emission for DNA affinity and live-cell imaging

    H. Liu, Z. Zhang, Y. Zhao, Y. Zhou, B. Xue, Y. Han, Y. Wang, X. Mu, S. Zang, X. Zhou and Z. Li, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C8TB03206H

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