Jump to main content
Jump to site search

Issue 9, 2019
Previous Article Next Article

Nanomized tumor-microenvironment-active NIR fluorescent prodrug for ensuring synchronous occurrences of drug release and fluorescence tracing

Author affiliations

Abstract

Improving the bioavailability and tumor-targeting ability of a prodrug, as well as monitoring its active ingredient release in vivo, is still a challenge in cancer diagnosis and therapy. Herein, a specific nanomized tumor-microenvironment-active near-infrared (NIR) fluorescent DCM-S-GEM/PEG prodrug was developed as a potent monitoring platform, wherein we conjugated antitumor drug gemcitabine (GEM) and NIR fluorescent chromophore dicyanomethylene-4H-pyran (DCM) via glutathione (GSH)-activatable disulfide linker and encapsulated DCM-S-GEM into an amphiphilic polymer DSPE-mPEG by self-assembly. The nanomized DCM-S-GEM/PEG prodrug exhibits excellent photostability and high biocompatibility, significantly improving the therapeutic efficacy toward lung tumor cells with fewer side-effects toward normal cells. Furthermore, when compared with the standalone DCM-S-GEM prodrug, the micellization with diblock DSPE-mPEG avoids fast metabolism, facilitates the accumulation of drugs in lung tumor tissues, displays longer tumor retention, and realizes precise drug release in lung tumors. The nanomized DCM-S-GEM/PEG prodrug can be developed as a promising tool to monitor prodrug delivery and activation processes in vivo.

Graphical abstract: Nanomized tumor-microenvironment-active NIR fluorescent prodrug for ensuring synchronous occurrences of drug release and fluorescence tracing

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Dec 2018, accepted on 18 Jan 2019 and first published on 18 Jan 2019


Article type: Paper
DOI: 10.1039/C8TB03188F
Citation: J. Mater. Chem. B, 2019,7, 1503-1509

  •   Request permissions

    Nanomized tumor-microenvironment-active NIR fluorescent prodrug for ensuring synchronous occurrences of drug release and fluorescence tracing

    Q. Li, J. Cao, Q. Wang, J. Zhang, S. Zhu, Z. Guo and W. Zhu, J. Mater. Chem. B, 2019, 7, 1503
    DOI: 10.1039/C8TB03188F

Search articles by author

Spotlight

Advertisements