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Enzymatic Crosslinking to Fabricate Antioxidant Peptide-based Supramolecular Hydrogel for Improving Cutaneous Wound Healing

Abstract

Peptide-based supramolecular hydrogels are promising scaffold materials and have been utilized in many fields. The mechanical properties of peptide hdyrogels are usually enhanced by synthetic or natural polymers to expand their application scope. In this study, antioxidant supramolecular hydrogels based on feruloyl-modified peptide and glycol chitosan are fabricated via mild laccase-mediated crosslinking reaction. Natural polysaccharide derivative—feruloyl glycol chitosan (GC-Fer) was used to enhance the mechanical properties of peptide hydrogels. Feruloyl groups are introduced into gel matrix via covalent bonds, which endows hydrogel inherent antioxidant properties. This is benifical for their in vivo application via scavenging harmful free radicals existed in the cutaneous wound. The further in vivo experiments demonstrated that the feruloyl-containing antioxidant hydrogel can improve cutaneous wound healing process. Regeneration process of mature epithelium and connective tissue were accelerated in a full-thick skin defect model.

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Publication details

The article was received on 29 Nov 2018, accepted on 11 Feb 2019 and first published on 13 Feb 2019


Article type: Paper
DOI: 10.1039/C8TB03147A
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript

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    Enzymatic Crosslinking to Fabricate Antioxidant Peptide-based Supramolecular Hydrogel for Improving Cutaneous Wound Healing

    Q. Wei, J. Duan, G. Ma, W. Zhang, Q. Wang and Z. Hu, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C8TB03147A

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