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Issue 8, 2019
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Synthesis, self-assembly behaviours and multivalent glycosidase inhibition effects of a deoxynojirimycin modified perylene bisimide derivative

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Abstract

A self-assembled multivalent glycosidase inhibitor based on perylene bisimide-deoxynojirimycin conjugates was constructed, inhibited α-mannosidase and exhibited a Ki value of 38 nM, increased approximately 2763-fold compared with the control drug (miglitol). Furthermore, the postprandial blood glucose (PBG) level in mice of PBI-DNJ was firstly studied. PBI-DNJ exhibited a hypoglycaemic effect in vivo. Importantly, this work developed a new means to explore the hypoglycaemic effect in mice based on self-assembled glycosidase inhibitors.

Graphical abstract: Synthesis, self-assembly behaviours and multivalent glycosidase inhibition effects of a deoxynojirimycin modified perylene bisimide derivative

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Publication details

The article was received on 27 Nov 2018, accepted on 22 Jan 2019 and first published on 23 Jan 2019


Article type: Paper
DOI: 10.1039/C8TB03122C
Citation: J. Mater. Chem. B, 2019,7, 1270-1275

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    Synthesis, self-assembly behaviours and multivalent glycosidase inhibition effects of a deoxynojirimycin modified perylene bisimide derivative

    J. Li, K. Wang, R. Li, J. Yang, M. Li, H. Zhang, Z. Cao and X. Li, J. Mater. Chem. B, 2019, 7, 1270
    DOI: 10.1039/C8TB03122C

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