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Negative Correlation between Water Content and Protein Adsorption on Polymer Brushes

Abstract

The correlation between water content and protein adsorption on the surface of polymer brushes is investigated quantitatively. Using a number of model system such as poly N-isopropylacrylamide (PNIPAM), polyethylene glycol (PEG), poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC), poly(2-hydroxyethyl methacrylate) (PHEMA), and poly (2,2,3,4,4,4-hexafluorobutyl) methacrylate (PHFBMA) polymer brushes with various grafting density, the amount of water hydrodynamically coupled inside the brushes and its correlation with protein adsorption (BSA and Fg protein as model systems) was characterized by quartz crystal microbalance with dissipation (QCM-D) and surface plasma resonance (SPR). The results demonstrate the negative correlation between the water content and protein adsorption – the more water is coupled inside the brushes; the more protein adsorption is suppressed. Especially for PNIPAM brushes with high enough grafting density with the water content beyond the value of 250 ng cm-2, the protein adsorption is negligible.

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Publication details

The article was received on 20 Nov 2018, accepted on 11 Feb 2019 and first published on 13 Feb 2019


Article type: Paper
DOI: 10.1039/C8TB03061H
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript

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    Negative Correlation between Water Content and Protein Adsorption on Polymer Brushes

    W. Dai, C. zheng , B. Zhao , K. Chen, P. Jia, J. Yang and J. Zhao, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C8TB03061H

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