Jump to main content
Jump to site search

Issue 13, 2019
Previous Article Next Article

A negative correlation between water content and protein adsorption on polymer brushes

Author affiliations

Abstract

The correlation between the water content and protein adsorption on the surface of polymer brushes is investigated quantitatively. Using a number of model systems such as poly N-isopropylacrylamide (PNIPAM), polyethylene glycol (PEG), poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC), poly(2-hydroxyethyl methacrylate) (PHEMA), and poly(2,2,3,4,4,4-hexafluorobutyl)methacrylate (PHFBMA) polymer brushes with various grafting densities, the amount of water hydrodynamically coupled inside the brushes and its correlation with protein adsorption (BSA and Fg proteins as model systems) were determined by quartz crystal microbalance with dissipation (QCM-D) and surface plasma resonance (SPR). The results demonstrate the negative correlation between the water content and protein adsorption – the more water is coupled inside the brushes, the more protein adsorption is suppressed. In particular for PNIPAM brushes with a high enough grafting density and with a water content greater than 250 ng cm−2, the protein adsorption is negligible.

Graphical abstract: A negative correlation between water content and protein adsorption on polymer brushes

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Nov 2018, accepted on 11 Feb 2019 and first published on 13 Feb 2019


Article type: Paper
DOI: 10.1039/C8TB03061H
Citation: J. Mater. Chem. B, 2019,7, 2162-2168

  •   Request permissions

    A negative correlation between water content and protein adsorption on polymer brushes

    W. Dai, C. Zheng, B. Zhao, K. Chen, P. Jia, J. Yang and J. Zhao, J. Mater. Chem. B, 2019, 7, 2162
    DOI: 10.1039/C8TB03061H

Search articles by author

Spotlight

Advertisements