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Design and synthesis of a fluorescent amino poly(glycidyl methacrylate) for efficient gene delivery

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Abstract

A fluorescent amino poly(glycidyl methacrylate) (PGOHMA) was synthesized by atom transfer radical polymerization (ATRP) and post-polymerization. The obtained star polymer PGOHMA has eight polymer arms enriched with amine groups for gene delivery. PGOHMA showed much lower cytotoxicity and higher delivery efficiency, compared with the widely used commercial and previously reported gene carriers. Therefore, a new star-shaped fluorescent polymer was successfully synthesized and explored as an efficient gene carrier.

Graphical abstract: Design and synthesis of a fluorescent amino poly(glycidyl methacrylate) for efficient gene delivery

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Publication details

The article was received on 10 Nov 2018, accepted on 31 Jan 2019 and first published on 04 Feb 2019


Article type: Paper
DOI: 10.1039/C8TB02968G
Citation: J. Mater. Chem. B, 2019, Advance Article

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    Design and synthesis of a fluorescent amino poly(glycidyl methacrylate) for efficient gene delivery

    H. Chen, S. You, Q. Cai, Y. Zheng, L. Zhang, J. Shen and M. Yin, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C8TB02968G

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