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Microcapsules-embedded hydrogel patches for ultrasound responsive and enhanced transdermal delivery of diclofenac sodium

Abstract

Transdermal delivery of diclofenac sodium (DS) has drawn much attention for the advantages of avoiding first-pass metabolism, reduced systemic toxicity and better patient compliance, but the successful translation of reported transdermal drug delivery systems (TDDSs) is still limited by poor skin permeability and uncontrollable drug release. Herein, we designed and fabricated a novel ultrasound responsive TDDS by embedding DS-loaded polyester microcapsules into a hydrogel patch based on four armed poly(ethylene glycol). The rational design endows the microcapsules-embedded hydrogel patch with good biocompatibility, excellent skin-adhesion property and well-controlled ultrasound responsive release behavior. More importantly, by employing ultrasound as a trigger of drug release and an efficient penetration enhancer simultaneously, the encapsulated drug could be released and pass through the skin barrier rapidly under ultrasound, while without action of ultrasound negligible amount of drug was released and penetrated into the subcutaneous tissues in ex vivo and in vivo transdermal drug release experiments, indicating improved and controllable transdermal delivery of DS was achieved. Our work demonstrated that the microcapsules-embedded hydrogel patch may be a promising candidate as ultrasound responsive and enhanced TDDS of DS for treating diseases such as arthritis and topical soft tissue injuries.

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Publication details

The article was received on 06 Nov 2018, accepted on 02 Feb 2019 and first published on 11 Feb 2019


Article type: Paper
DOI: 10.1039/C8TB02928H
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript

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    Microcapsules-embedded hydrogel patches for ultrasound responsive and enhanced transdermal delivery of diclofenac sodium

    D. Huang, M. Sun, Y. Bu, F. Luo, C. Lin, Z. Lin, Z. Weng, F. Yang and D. Wu, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C8TB02928H

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