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Hollow carbon nanospheres derived from biomass by-product okara for imaging-guided photothermal therapy of cancers

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Abstract

Okara is a by-product of tofu manufacturing and is usually used as a feedstuff. Herein, we developed a methodology of using okara as a carbon source for the preparation of photothermal nano-materials. It's interesting to find that just after calcination, the carbonized okara forms sphere-shaped hollow particles (denoted as HCNS) with an average diameter of 200 nm. Owning to the existence of a cavity, the HCNS was found to exhibit not only a good photothermal conversion efficiency, but also an ideal photoacoustic imaging property, which makes it a promising agent for imaging-guided photothermal therapy (PTT). The high photothermal conversion efficiency can result from the high carbon content and its hollow morphology. The in vitro and in vivo results both demonstrated the biocompatibility and capacity of the plant source carbon spheres for NIR-triggered cancer treatment. Therefore, the current work suggests a new method to gain a safe and low-cost photothermal platform which could be further exploited in biomedical fields.

Graphical abstract: Hollow carbon nanospheres derived from biomass by-product okara for imaging-guided photothermal therapy of cancers

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Publication details

The article was received on 30 Oct 2018, accepted on 31 Jan 2019 and first published on 04 Feb 2019


Article type: Paper
DOI: 10.1039/C8TB02858C
Citation: J. Mater. Chem. B, 2019, Advance Article

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    Hollow carbon nanospheres derived from biomass by-product okara for imaging-guided photothermal therapy of cancers

    Y. Weng, S. Guan, L. Wang, X. Qu and S. Zhou, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C8TB02858C

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