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Functionalized-Ferroelectric-Coatings-Driven Enhanced Biomineralization and Protein-Conformation on Metallic Implants

Abstract

In the context of bone regeneration, it is important to have platforms that with appropriate stimuli can support the attachment and direct the growth, proliferation and differentiation of the cells. In the orthopedic field, metals and alloys are still the dominant materials used as implants, though their bioinert character leads to failure or to the need of multiple revision procedures. To respond to this situation here we exploit an alternative strategy for bone implants or repairs, based on charged mediating signals for bone regeneration, envisaged as a type of biological micro-electromechanical systems (BioMEMs). This strategy includes coating metallic 316L-type stainless steel (316L-SST) substrates with ferroelectric LiTaO3 (LTO) layers functionalized via electrical charging or UV-light irradiation. We show that the formation of surface calcium phosphates and protein adsorption are considerably enhanced for 316L-SST functionalized ferroelectric coatings. Our findings go beyond the current knowledge and demonstrate that the protein conformation is sensitive to the type of charge functionalization of the ferroelectric coatings. Our approach can be viewed as a set of guidelines for the development of platforms electrically functionalized that can stimulate tissue regeneration promoting direct integration of the implant in the host tissue and, hence contributing ultimately to reduce implant failure.

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Publication details

The article was received on 21 Oct 2018, accepted on 11 Feb 2019 and first published on 13 Feb 2019


Article type: Paper
DOI: 10.1039/C8TB02777C
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript

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    Functionalized-Ferroelectric-Coatings-Driven Enhanced Biomineralization and Protein-Conformation on Metallic Implants

    S. Złotnik, M. Maltez da Costa, N. Barroca, M. Hortigüela Gallo, M. K. Singh, M. H. V. Fernandes and P. M. Vilarinho, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C8TB02777C

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