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Magnetic nanoarchitectures for cancer sensing, imaging and therapy

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Abstract

The use of magnetic nanoparticles for sensing and theranostics of cancer has grown substantially in the last decade. Since the pioneering studies, which reported magnetic nanoparticles for bio-applications more than fifteen years ago, nanomaterials have increased in complexity with different shapes (nanoflowers, nanospheres, nanocubes, nanostars etc.) and compositions (e.g. core–shell) of nanoparticles for an increase in the sensitivity (imaging or sensing) and efficiency through synergistic treatments such as hyperthermia and drug delivery. In this review, we describe recent examples concerning the use of magnetic nanoparticles for bio-applications, from the surface functionalization methods to the development of cancer sensors and nanosystems for magnetic resonance and other imaging methodologies. Multifunctional nanosystems (nanocomposites, core shell nanomaterials) for theranostic applications involving treatments such as hyperthermia, photodynamic therapy, targeted drug delivery, and gene silencing are also described. These nanomaterials could be the future of medicine, although their complexity raises concerns about their safety.

Graphical abstract: Magnetic nanoarchitectures for cancer sensing, imaging and therapy

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Publication details

The article was received on 17 Oct 2018, accepted on 23 Nov 2018 and first published on 26 Nov 2018


Article type: Review Article
DOI: 10.1039/C8TB02741B
Citation: J. Mater. Chem. B, 2019, Advance Article
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    Magnetic nanoarchitectures for cancer sensing, imaging and therapy

    N. Ž. Knežević, I. Gadjanski and J. Durand, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C8TB02741B

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