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Issue 12, 2019
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Fluorescent nitric oxide donor for the detection and killing of Pseudomonas aeruginosa

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Abstract

The epidemic of multidrug-resistant bacteria calls for the improvement of both detection methods for bacterial infections and methods of treatment. Nitric oxide is a known potent antibacterial agent, but due to its gaseous and highly reactive nature, it is difficult to incorporate into a stable antibacterial compound. In this paper, we synthesize a nitric oxide donor attached to a fluorescent compound, creating a material that can both detect and kill the deadly multi-drug resistant bacteria strain Pseudomonas aeruginosa. Detection occurs through a bacterial enzyme-activated color change, showing a clear and obvious change from blue to yellow under UV light. The synthesized compound spontaneously releases 853 μmol of nitric oxide/g from a 10 mM initial concentration. Antibacterial efficacy studies after exposing Pseudomonas aeruginosa to a 10 mM dose of the synthesized compound show a 55–75% reduction in bacteria after 24 hours. This work is the first instance of a small molecule dual-function material that can both detect and kill bacteria.

Graphical abstract: Fluorescent nitric oxide donor for the detection and killing of Pseudomonas aeruginosa

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Publication details

The article was received on 27 Sep 2018, accepted on 29 Jan 2019 and first published on 29 Jan 2019


Article type: Paper
DOI: 10.1039/C8TB02552E
Citation: J. Mater. Chem. B, 2019,7, 2009-2018

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    Fluorescent nitric oxide donor for the detection and killing of Pseudomonas aeruginosa

    H. A. J. Hibbard and M. M. Reynolds, J. Mater. Chem. B, 2019, 7, 2009
    DOI: 10.1039/C8TB02552E

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