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Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions

Abstract

Implant infection is one of the most severe complications after orthopedic surgery. The construction of an antibacterial coating on orthopedic implants with release-killing or contact-killing is one of the most efficient strategies to prevent implant-related infections. Here we reported a hydroxypropyltrimethyl ammonium chloride chitosan (HACC) based multilayer modified plasma-sprayed porous titanium coating generated via the layer-by-layer covalent-immobilized method. We demonstrated that the multilayer coating inhibited the colonization and biofilm formation of several bacterial strains, including Staphylococcus aureus (ATCC 25923), methicillin-resistant Staphylococcus aureus (MSRA, ATCC 43300) and clinical isolate methicillin-resistant Staphylococcus epidermidis (MRSE 287) in vitro. The HACC in the multilayer was released slowly with the degradation of the coating under the action of collagenase, further killing the planktonic bacteria, while the remaining HACC could kill the colonized bacteria. In a rat model of femurs implants, the HACC-based multilayer-modified TCs effectively controlled the infection caused by MRSA and prevented the bone destruction. Therefore, the HACC-based multilayer modified TCs with multiple antimicrobial properties could be a new potential ideal surface modification strategy to prevent implants associated infections.

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Publication details

The article was received on 13 Sep 2018, accepted on 03 Feb 2019 and first published on 05 Feb 2019


Article type: Paper
DOI: 10.1039/C8TB02425A
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript

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    Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions

    H. Ao, S. Yang, B. Nie, Q. Fan, Q. Zhang, J. Zong, S. Guo, X. Zheng and T. Tang, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C8TB02425A

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