S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE−/− mice

Jooneon Park; Huiyun Gao; Yunmei Wang; He Hu; Daniel I. Simon; Nicole F. Steinmetz

doi:10.1039/C8TB02276C

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE^−/− mice†

Jooneon Park,

^ab Huiyun Gao,^c Yunmei Wang,^c He Hu,^ab Daniel I. Simon^cd and Nicole F. Steinmetz

*^abef

Author affiliations

* Corresponding authors

^a Department of Nanoengineering, University of California San Diego, La Jolla, CA 92093, USA
E-mail: nsteinmetz@ucsd.edu

^b Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA

^c Harrington Heart and Vascular Institute, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA

^d University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA

^e Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA

^f Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA

Abstract

We integrate a biocompatible plant virus-based nanotechnology (tobacco mosaic virus, TMV) with S100A9-targeting peptides for its application in imaging and diagnosis of atherosclerosis. S100A9-targeted TMV nanoparticles exhibit remarkable specificity to S100A9 and targeting of atherosclerosis lesions in ApoE^−/− mice.

Download options Please wait...

Supplementary files

Supplementary information PDF (4884K)

Article information

DOI: https://doi.org/10.1039/C8TB02276C
Article type: Communication
Submitted: 28 Aug 2018
Accepted: 04 Feb 2019
First published: 13 Feb 2019

Download Citation

J. Mater. Chem. B, 2019,7, 1842-1846

Permissions

Request permissions

S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE^−/− mice

J. Park, H. Gao, Y. Wang, H. Hu, D. I. Simon and N. F. Steinmetz, J. Mater. Chem. B, 2019, 7, 1842 DOI: 10.1039/C8TB02276C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Journal of Materials Chemistry B