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Efficient capture and photothermal ablation of planktonic bacteria and biofilms using reduced graphene oxide–polyethyleneimine flexible nanoheaters

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Abstract

Bacterial infections are one of the leading causes of disease worldwide. Conventional antibiotics are becoming less efficient, due to antibiotic-resistant bacterial strains. Therefore, the development of novel antibacterial materials and advanced treatment strategies are becoming increasingly important. In the present work, we developed a simple and efficient strategy for effective bacterial capture and their subsequent eradication through photothermal killing. The developed device consists of a flexible nanoheater, comprising a Kapton/Au nanoholes substrate, coated with reduced graphene oxide–polyethyleneimine (K/Au NH/rGO–PEI) thin films. The Au NH plasmonic structure was tailored to feature strong absorption in the near-infrared (NIR) region, where most biological matter has limited absorption, while PEI was investigated for its strong binding with bacteria through electrostatic interactions. The K/Au NH/rGO–PEI device was demonstrated to capture and eliminate effectively both planktonic Gram-positive Staphilococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 10 min of NIR (980 nm) irradiation and, to destroy and eradicate Staphilococcus epidermidis (S. epidermidis) biofilms after 30 min irradiation. The technique developed herein is simple and universal with potential applications for eradication of different micro-organisms.

Graphical abstract: Efficient capture and photothermal ablation of planktonic bacteria and biofilms using reduced graphene oxide–polyethyleneimine flexible nanoheaters

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Publication details

The article was received on 26 Jun 2018, accepted on 26 Mar 2019 and first published on 27 Mar 2019


Article type: Paper
DOI: 10.1039/C8TB01676C
Citation: J. Mater. Chem. B, 2019, Advance Article

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    Efficient capture and photothermal ablation of planktonic bacteria and biofilms using reduced graphene oxide–polyethyleneimine flexible nanoheaters

    M. Budimir, R. Jijie, R. Ye, A. Barras, S. Melinte, A. Silhanek, Z. Markovic, S. Szunerits and R. Boukherroub, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C8TB01676C

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