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Single-Photon-Driven Up-/Downconversion Nanohybrids for In vivo Mercury Detection and Real-Time Tracking

Abstract

A multifunctional assay with up-/downconversion (UC/DC) nanohybrids that enables the detection and real-time tracking of hazardous molecules has been developed for use in the field of photoluminescence (PL) point-of-care testing due to its cost and convenience. In particular, innovative approaches such as dual or multimodal imaging and detection under only a single-photon pulse system are highly difficult owing to the issues of device simplification and miniaturization. In this work, we first demonstrated single-photon-driven UC/DC dual-modal PL nanohybrids and showed their high performance in in vivo mercury detection and real-time tracking in a mussel simultaneously. Specifically, UC/DC nanohybrids capable of being stimulated by a single photon were presented via a facile and versatile strategy by combining DC fluorophores for heavy metal ion screening with triplet-triplet annihilation upconversion (TTA-UC) nanocapsules for real-time tracking. By adopting the advantages of the structural transformation of DC fluorophore and highly stable TTA-UC nanocapsules, the outstanding monitoring performance of standard heavy metal ion (i.e. Hg2+) was achieved by a dual-modal PL assay with nanohybrids, exhibiting the ultra-sensitivity (under 1 nM) and high-selectivity Interestingly, their application in the real world was also remarkable in screening and tracking of the mercury in mussels. This single-photon-driven UC/DC convergence system will provide powerful analytical methodologies for target detection and real-time tracking in vivo and will attract widespread attention from researchers in PL nanomaterials and fluorophores.

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Publication details

The article was received on 03 Oct 2019, accepted on 03 Dec 2019 and first published on 04 Dec 2019


Article type: Paper
DOI: 10.1039/C9TA10921H
J. Mater. Chem. A, 2019, Accepted Manuscript

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    Single-Photon-Driven Up-/Downconversion Nanohybrids for In vivo Mercury Detection and Real-Time Tracking

    S. E. Seo, C. S. Park, S. J. Park, K. H. Kim, J. Lee, J. Kim, S. H. Lee, H. S. Song, T. H. Ha, J. Kim, H. W. Yim, H. Kim and O. S. kwon, J. Mater. Chem. A, 2019, Accepted Manuscript , DOI: 10.1039/C9TA10921H

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