Jump to main content
Jump to site search


Preparation of electrospray ALG/PDA–PVP nanocomposites and their application in cancer therapy

Author affiliations

Abstract

In this study, sodium alginate (ALG)/poly dopamine (PDA)–polyvinylpyrrolidone (PVP) nanocomposites was synthesized via a one-step electrostatic spraying method. The spinning solution of ALG and dopamine was electrostatically sprayed into an alkaline solution of PVP, calcium chloride and tris buffer (pH = 8.5), in which the gelation of ALG and the polymerization of dopamine could be simultaneously triggered. PDA hence produced possesses a high photothermal conversion efficiency, while the PVP that was facilely conjugated onto the surface of nanocomposites improves the colloidal stability and compatibility of the material. Moreover, the ALG renders the nanocomposite excellent drug (doxorubicine, DOX) loading capacity. Promisingly, the temperature increment during the PTT process could promote the DOX release, thus enhancing its therapeutic effect. The in vitro/in vivo biosafety and tumor treatment experiments further corroborate that the ALG/PDA–PVP nanocomposites have remarkable biocompatibility and synergism for tumor hyperthermia and chemotherapy. Consequently, such a one-step electrospray strategy provides a new way for designing nanomaterials and is expected to significantly promote the development of organic photothermal therapeutic agents with excellent bio-compatibility.

Graphical abstract: Preparation of electrospray ALG/PDA–PVP nanocomposites and their application in cancer therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Aug 2019, accepted on 03 Nov 2019 and first published on 04 Nov 2019


Article type: Paper
DOI: 10.1039/C9SM01584A
Soft Matter, 2019, Advance Article

  •   Request permissions

    Preparation of electrospray ALG/PDA–PVP nanocomposites and their application in cancer therapy

    Y. Xu, J. Zhao, Z. Zhang, J. Zhang, M. Huang, S. Wang and P. Xie, Soft Matter, 2019, Advance Article , DOI: 10.1039/C9SM01584A

Search articles by author

Spotlight

Advertisements