Preparation of electrospray ALG/PDA-PVP nanocomposites and its application in cancer therapy
In this research, the sodium alginate (ALG)/poly dopamine (PDA)-polyvinylpyrrolidone (PVP) nanocomposites was synthesized via the one-step electrostatic spraying method. The spinning solution of ALG and dopamine was electrostatically sprayed into an alkaline solution of PVP, calcium chloride and Tris buffer (pH = 8.5), in which the gelation of ALG and the polymerization of dopamine could be simultaneously triggered. The PDA thence produced possesses a high photothermal conversion efficiency, while the PVP which was facilely conjugated onto the surface of nanocomposites, improves the colloidal stability and compatibility of the material. Moreover, the sodium alginate renders the nanocomposite excellent drug (doxorubicine, DOX) loading capacity. Promisingly, the temperature increment during the PTT process could promote the DOX release and thus enhance its therapeutic effect. The in vitro/in vivo biosafety and tumor treatment experiments further corroborate that the ALG/PDA-PVP nanocomposites have remarkable biocompatibility and synergism tumor hyperthermia and chemotherapy. Consequently, such a one-pot electrospray strategy provides a new way of designing nanomaterial and is expected to promote the development of organic photothermal therapeutic agents with excellent bio-compatibility significantly.